الفا فيټوپروټين
الفا فيټوپروټين (په انگرېزي: Alpha-fetoprotein AFP, α-fetoprotein; alpha-1-fetoprotein, alpha-fetoglobulin او يا هم alpha fetal protein) يو ډول پروټين دی[۱][۲] چې په انسانانو کې د AFP جين لخوا په کوډونو سمبال شوی.[۳][۴]د AFP جين د کروموزوم 4 په q مټ موقعيت لري (4q25).
الفا فيټوپروټين په پلازما کې يو عمده پروټين دی چې د جنين د ودې په بهير کې په لړمانه او نوکڅوړې کې جوړېږي. داسې گڼل کېږي چې همدا پروټين د جنيني بڼې البوميني سېروم دی. AFP د تامبې, نېکل, شحمي اسيدونو او بيليروبين سره د تړل کېدلو توان لري[۴] او د پروټينونو په مونومېريک، ډايمېرېک او ټرايمېرېک بڼو کې موندل کېږي.
جوړښت
الفا فيټوپروټين يو گلايکوپروټين دی چې د ۵۹۱ امينو اسيدونو[۵] او د کاربوهايډرېټو عاملي ډلو څخه جوړ شوی.[۶]
کړنه
الفافيټوپروټين هغه پلازما پروټين دی چې تر ټولو ډېر په انساني جنين کې موندل کېږي.
دا هم ولولئ
سرچينې
- ↑ Tomasi TB (1977). "Structure and function of alpha-fetoprotein". Annual review of medicine. 28: 453–65. doi:10.1146/annurev.me.28.020177.002321. PMID 67821.
- ↑ Mizejewski GJ (May 2001). "Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants". Experimental Biology and Medicine. 226 (5): 377–408. PMID 11393167. Archived from the original on 2009-12-05. نه اخيستل شوی 2015-02-16.
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ignored (help) - ↑ Harper ME, Dugaiczyk A (July 1983). "Linkage of the evolutionarily-related serum albumin and alpha-fetoprotein genes within q11-22 of human chromosome 4". American Journal of Human Genetics. 35 (4): 565–72. PMC 1685723. PMID 6192711.
- ↑ ۴٫۰ ۴٫۱ "Entrez Gene: Alpha-fetoprotein".
- ↑ Pucci P, Siciliano R, Malorni A, Marino G, Tecce MF, Ceccarini C, Terrana B (May 1991). "Human alpha-fetoprotein primary structure: a mass spectrometric study". Biochemistry. 30 (20): 5061–6. doi:10.1021/bi00234a032. PMID 1709810.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - ↑ Seregni E, Botti C, Bombardieri E (1995). "Biochemical characteristics and clinical applications of alpha-fetoprotein isoforms". Anticancer Res. 15 (4): 1491–9. PMID 7544570.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)
لا نورې لوستنې
- Nahon JL (1987). "The regulation of albumin and alpha-fetoprotein gene expression in mammals". Biochimie. 69 (5): 445–59. doi:10.1016/0300-9084(87)90082-4. PMID 2445387.
- Tilghman SM (1989). "The structure and regulation of the alpha-fetoprotein and albumin genes". Oxf. Surv. Eukaryot. Genes. 2: 160–206. PMID 2474300.
- Mizejewski GJ (2003). "Biological role of alpha-fetoprotein in cancer: prospects for anticancer therapy". Expert Rev Anticancer Ther. 2 (6): 709–35. doi:10.1586/14737140.2.6.709. PMID 12503217.
- Yachnin S, Hsu R, Heinrikson RL, Miller JB (1977). "Studies on human alpha-fetoprotein. Isolation and characterization of monomeric and polymeric forms and amino-terminal sequence analysis". Biochim. Biophys. Acta. 493 (2): 418–28. doi:10.1016/0005-2795(77)90198-2. PMID 70228.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Aoyagi Y, Ikenaka T, Ichida F (1977). "Comparative chemical structures of human alpha-fetoproteins from fetal serum and from ascites fluid of a patient with hepatoma". Cancer Res. 37 (10): 3663–7. PMID 71198.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Aoyagi Y, Ikenaka T, Ichida F (1978). "Copper(II)-binding ability of human alpha-fetoprotein". Cancer Res. 38 (10): 3483–6. PMID 80265.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Aoyagi Y, Ikenaka T, Ichida F (1979). "alpha-Fetoprotein as a carrier protein in plasma and its bilirubin-binding ability". Cancer Res. 39 (9): 3571–4. PMID 89900.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Torres JM, Anel A, Uriel J (1992). "Alpha-fetoprotein-mediated uptake of fatty acids by human T lymphocytes". J. Cell. Physiol. 150 (3): 456–62. doi:10.1002/jcp.1041500305. PMID 1371512.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Greenberg F, Faucett A, Rose E; et al. (1992). "Congenital deficiency of alpha-fetoprotein". Am. J. Obstet. Gynecol. 167 (2): 509–11. PMID 1379776.
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(help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Bansal V, Kumari K, Dixit A, Sahib MK (1991). "Interaction of human alpha fetoprotein with bilirubin". Indian J. Exp. Biol. 28 (7): 697–8. PMID 1703124.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Pucci P, Siciliano R, Malorni A; et al. (1991). "Human alpha-fetoprotein primary structure: a mass spectrometric study". Biochemistry. 30 (20): 5061–6. doi:10.1021/bi00234a032. PMID 1709810.
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(help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Liu MC, Yu S, Sy J; et al. (1985). "Tyrosine sulfation of proteins from the human hepatoma cell line HepG2". Proceedings of the National Academy of Sciences of the United States of America. 82 (21): 7160–4. doi:10.1073/pnas.82.21.7160. PMC 390808. PMID 2414772.
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(help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Gibbs PE, Zielinski R, Boyd C, Dugaiczyk A (1987). "Structure, polymorphism, and novel repeated DNA elements revealed by a complete sequence of the human alpha-fetoprotein gene". Biochemistry. 26 (5): 1332–43. doi:10.1021/bi00379a020. PMID 2436661.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Sakai M, Morinaga T, Urano Y; et al. (1985). "The human alpha-fetoprotein gene. Sequence organization and the 5' flanking region". J. Biol. Chem. 260 (8): 5055–60. PMID 2580830.
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(help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Ruoslahti E, Pihko H, Vaheri A; et al. (1975). "Alpha fetoprotein: structure and expression in man and inbred mouse strains under normal conditions and liver injury". Johns Hopkins Med. J. Suppl. 3: 249–55. PMID 4138095.
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(help)سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Urano Y, Sakai M, Watanabe K, Tamaoki T (1985). "Tandem arrangement of the albumin and alpha-fetoprotein genes in the human genome". Gene. 32 (3): 255–61. doi:10.1016/0378-1119(84)90001-5. PMID 6085063.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link) - Beattie WG, Dugaiczyk A (1983). "Structure and evolution of human alpha-fetoprotein deduced from partial sequence of cloned cDNA". Gene. 20 (3): 415–22. doi:10.1016/0378-1119(82)90210-4. PMID 6187626.
- Morinaga T, Sakai M, Wegmann TG, Tamaoki T (1983). "Primary structures of human alpha-fetoprotein and its mRNA". Proceedings of the National Academy of Sciences of the United States of America. 80 (15): 4604–8. doi:10.1073/pnas.80.15.4604. PMC 384092. PMID 6192439.
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: سرچينه ساتل:څونوميز:ليکوالانو نوملړ (link)